which medications should not be taken with grapefruit

When an interaction between grapefruit and medication occurs, it is due to furanocoumarins and flavonoids inhibiting the enzyme cytochrome P450, an enzyme responsible for the metabolism of drugs in the liver. 2 Furanocoumarins and flavanones are the main active components in grapefruit that are responsible for medication interactions. Grapefruit’s bioactive phytochemicals have been demonstrated to have a variety of health-promoting qualities like anti-inflammation and anti-oxidation, but certain components have also been linked to negative side effects when combined with other drugs. The Interaction Between Grapefruit and Drugs Fruit extracts in liquid form are another popular and useful choice. Grapefruit and its seeds can be freeze dried and processed into a powder to create supplements in the forms of capsules or tablets. The grapefruit’s pectin, fruit juice, and oils-all rich in vitamins and bioactive compounds-are used to produce grapefruit supplements. A single serving of this fruit contains 100% of the Recommended Daily Allowance of vitamin C! 4 Due to the grapefruit’s capacity to offer nutritional advantages, the fruit is processed into a variety of dietary supplements. Grapefruits are an excellent food source. 2 Not only are they rich in vitamins and minerals, but also contains a great number of bioactive phytochemicals, including flavonoids, carotenoids, coumarins, and organic acids, making the fruit notable for its anti-oxidative, anti-inflammatory, and neuroprotective properties. 3 Grapefruits are high in vitamin C, dietary fiber, and minerals. The citrus fruit is desirable due to its high nutritional content. 2 Although grapefruits have therapeutic benefits due to their high nutritional content, they also contain certain components that may interact negatively with medications. 1 The grapefruit, which is a cross between a sweet orange and a pomelo, is remarkable for the variety of nutrients it has to offer. The fourth-most often cultivated citrus species in the world is grapefruit with oranges, tangerines, and lemons being the first three in that order. By: Carlos Alaniz, CSUN Dietetic Intern Cohort 2021-2023

Which medications should not be taken with grapefruit